2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100843
    L-AP6 78944-89-5 98%
    L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    L-AP6
  • HY-100915
    SKF 97541 127729-35-5 98%
    SKF 97541 (CGP 35024) is a potent and selective GABAB agonist that can induce hyperpotential. SKF 97541 has antiepileptic activity.
    SKF 97541
  • HY-100916
    Arecaidine-propargyl ester tosylate 147202-94-6 98%
    Arecaidine-propargyl ester tosylate is a potent muscarinic receptor (mAChR) agonist.
    Arecaidine-propargyl ester tosylate
  • HY-100922
    N-Acetylglycyl-D-glutamic acid 135701-69-8 98%
    N-Acetylglycyl-D-glutamic acid is a peptide with excitatory effect. N-Acetylglycyl-D-glutamic acid induces seizures in mice.
    N-Acetylglycyl-D-glutamic acid
  • HY-100924
    β-CCB 84454-35-3 98%
    β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [3H]flunitrazepam and ethyl (3-[3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects.
    β-CCB
  • HY-100930
    L-693403 maleate 207455-21-8 98%
    L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research.
    L-693403 maleate
  • HY-100963
    U-54494A 112465-94-8 98%
    U-54494A is a benzamide derivative related to κ-opioid receptor agonists, U-54494A has an anticonvulsant activity.
    U-54494A
  • HY-100980
    HEAT hydrochloride 30007-39-7 98%
    HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.
    HEAT hydrochloride
  • HY-100981
    MR-16728 hydrochloride 207403-36-9 98%
    MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins.
    MR-16728 hydrochloride
  • HY-100998
    Metaphit 96316-00-6 98%
    Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms.
    Metaphit
  • HY-101008
    3-MPPI 133399-65-2 98%
    3-MPPI is a GPCR ligand with high selectivity for α1-adrenergic receptor, with a Ki value of 0.21 nM for α1-adrenergic receptor and 50 nM for 5-HT1A receptor. 3-MPPI modulates the α1-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia.
    3-MPPI
  • HY-101009
    Methiothepin maleate 19728-88-2 98%
    Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
    Methiothepin maleate
  • HY-101010
    Methylfurmethide iodide 1197-60-0 98%
    Methylfurmethide is an acetylcholine receptor. Methylfurmethide blocks the uptake of atropine. Methylfurmethide can be used to study the properties of acetylcholine receptors in intestinal smooth muscle .
    Methylfurmethide iodide
  • HY-101039
    AR-M 1000390 209808-01-5 98%
    AR-M 1000390 is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.
    AR-M 1000390
  • HY-101049
    CGS 12066 dimaleate 109028-10-6 98%
    CGS 12066 (dimaleate) dimaleate is a selective 5-HT1B receptor agonist with an IC50 of 51 nM.
    CGS 12066 dimaleate
  • HY-101062
    3-AQC 201216-42-4 99.45%
    3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist.
    3-AQC
  • HY-101080
    3'-Fluorobenzylspiperone maleate 1135278-61-3 98%
    3'-Fluorobenzylspiperone maleate is a ligand for dopamine D2 receptors with activity in improving behavioral disorders. 3'-Fluorobenzylspiperone maleate showed better inhibitory effects than placebo, especially in reducing behavioral disorders.
    3'-Fluorobenzylspiperone maleate
  • HY-101105
    SB-224289 180083-23-2 98%
    SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
    SB-224289
  • HY-101139
    Xanthine amine congener 96865-92-8 98%
    Xanthine amine congener is a non-selective adenosine receptor antagonist. Xanthine amine congener induces convulsions in mice.
    Xanthine amine congener
  • HY-101164
    MAP4 157381-42-5 98%
    MAP4 is a selective group III mGluR antagonist in some electrophysiological systems.
    MAP4
Cat. No. Product Name / Synonyms Application Reactivity